James Hamilton, M. D.
Mike,
In med school back in the early '70's, most of us would surely agree that neuroanatomy was the most difficult and complicated topic to master. Looking back and realizing what we have discovered in the past 50 years, that was like addition and subtraction compared to differential and integral calculus.
Memory is stored and chemically/electrcally transported among many places in the brain via neurons to synapses where several chemical neurotransmitters such as epinephrine, norepinephrine, glutamate, seratonin, gamma aminobuteric acid, dopamine and others are secreted. The hippocampus, whose major neurotransmitter is acetylcholine, is sort of the processor (akin to a computer processor) for the memory. Anatomically close to hippo are the two amygdalae nuclei which are also important in the memory processes.
Bottom line, many other brain structures participate in this train of chemicals which carry on various memory functions like recognizing taste, smell, faces, tasks, locations, knowledge and just about everything from long ago to what we did five minutes ago.
Neurotransmitters, of course, have other functions in the brain (and other organs) and medications are often used (especially in psychiatry) to modulate their amount in order to treat certain diseases and disorders.
Like all chemicals, I suspect that stored neurotransmitters that are storing information ("memory") eventually degrade and maybe that is why we forget certain things. Renewing those pathways on a regular basis may keep them supplied with fresh neurotransmitters. I guess this would be what I would call "use it or lose it".
As a medical/neurology/psychiatry/neuroscience arena of understanding we are probably not any longer in a state of infancy, but we are probably only in our pre-teen years. And as for therapeutic intervention (treatment), we are newborns.
Jim
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