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04/22/20 06:13 PM #7226    

 

James Hamilton, M. D.

Mike,  

That Chinese study on convalescent plasma therapy for COVID-19 has cornered a lot of attention from the medical community and further research is being conducted. I think that will confirm the efficacy of this treatment. As you may be aware now or may see as you research this topic for your article, immune globulin therapy is often used in treating a myriad of diseases and has been for some time. It has also been used prophylactically to prevent Hepatitis A in people exposed to or traveling to endemic areas of Hep A (although the vaccine has decreased the need for that in many patients). Herd immunity (on a community level), convalescent plasma (CP) and vaccines all result in an adequte immune response to the virus in many individuals. The question, particularly with CP, is how long will it last and will it interfere with the recipients' ability to generate their own IgG antibodies?

Jim 


04/22/20 10:10 PM #7227    

 

David Mitchell

Wow Mike!   Thank you for writing this great piece. Can't wait for the finished product.

I was just about to answer your post #7239 above with an almost exact copy of what Jim followed it with. How many times over the dinner table did I hear my dad wax on and on about this very thought. It is the notion that taking the time with the individual patient, looking them in the face, and touching them is actually a necessary part of most treatment. My dad used to use that exact phrase "laying on hands" and claimed it was "life giving".

I recall him ranting one night about a decison that had been made that day at OSU Medical School, where he served as a Department head for amost 45 years. Skipping some details - it was about a decison to accept one of the Juniors in pre-med, directly into Med School (a year early - a once common practice for a select few - not sure if they still do that?).

The board chose NOT to accept the one who was loved and respected by all for his wonderful, caring personality, becasue he only had a 3.7 grade accum (got a 'D' in his freshman German class and couple 'B's" somewhere else along the way. We knew him.) Instead they chose the guy with a 4.0 accum. who was an introverted, keep-to-himself, egghead that no one could warm up to. Dad was ready to explode when he got home for dinner.

I will never forget his quote, "This damn Medical School has gotten too damn political, and too damn expensive, and too damned important for it's own good. We're turning out technicians and not physicians! They know how to run every damn test known to man, but don't give a damn about the patient. 

(and that was back in the 60's)

This brings back thoughts from "The Road Less Traveled" by Scott Peck. He made the point loud and clear that no mater how much analysis and how many tests, real healing doesn't usually occur unless and until the Doctor actually "cares" for the patient.

 

I remember that book in just about evey bookstore window and on every grocery store checkout back in the 70's. My Dad practically begged me to read it but I wouldn't normally follow my dad's advice if you held a gun at my head. Then, after two failed atempts (first 100 pages is pretty technical and boring), I was having lunch with Kevin Ryan and Steve Hodges - 2 seperate occasions -  and they both said it was the most important book they had ever read. 'Nough said. I finished it and agree with Kevin and Steve (and Jim) whole-heartedly. 


04/23/20 11:36 AM #7228    

 

Michael Boulware

A good way to fillup time we have to spend in the house is by reading good books. Kevin Ryan suggested reading The Walt Longmire series by Craig Johnson. The series has been portrayed on Netflix. Kevin steered me in the right direction; they are really good novels.

My favorites are the Jack Reacher series by Lee Child. Reading those is like watching Rocky or Rambo. 

These are just suggestions how you can kill some time waiting for the coronavirus to get out of town. I hope some of our classmates add to the list.


04/23/20 12:53 PM #7229    

Mary Clare Hummer (Bauer)

Janie,

So many celebrations have to be put on hold for so many.  Watterson senior class parents sponsored and carried out a senior recognition surprise last night.  Participating parents each were assigned a list of kids’ addresses and went on a midnight delivery run. Hopefully, they'll be able to celebrate like we did in '66 sometime this summer.  


04/23/20 01:09 PM #7230    

 

Joseph D. McCarthy

First.  Mike, to add to your reading list I've mentioned to a couple classmates about an article in our local paper, and also the San Francisco Chronicle, about Jack London's 1910 short apocalyptic novel " The Scarlet Plague" about a 21st century pandemic in his home state (California).  London imagined a global epidemic in the year 2013 that killed........

Second.  Dr. Jim can you help with a discussion on hand washing during current conditions.  My wife has said that she heard that washing with soap and hot water would kill the virus.  I have said that washing with hot water Opens the pores in the skin, but does not kill a virus.  Thats in order to kill the virus with HOT it would have to be hot enough to give one third degree burns.  Somewhere in between is probably the right answer.  Your thoughts would be appreciated.

Joe

the Non-Scientist / Non-Medical expert

 


04/23/20 01:59 PM #7231    

 

James Hamilton, M. D.

Joe McC.,

There is still a debate about water temperature in regards to hand washing. Obviously, boiling hot water kills microorganisms but is not a practical way to disinfect skin. Most people will probably wash their hands longer in warm water than cold or very hot water. Soap will lather up better in warm/hot water than in cold and, therefore, will do a better job of cleansing and removing dirt and pathogens from the hands. Soap does tend to destroy the virus capsid (cover) and thus kills the virus. Hand sanitizers can also destroy the capsid but do not remove dirt and (supposedly dead) pathogens from the hands. So, hand washing is superior to sanitizers if properly performed. However, in a pinch, sanitizers are a good option if a sink is not available. Another point about hand washing: antibacterial soaps are most likely not much better - if at all - than plain soap.

Hope this helps! 

 

Jim 

 

 


04/23/20 02:47 PM #7232    

 

Alan Standish

Some suggestions for authors to read during these lousy times:  Michael Connelly, John Grisham, Harlan Coben, Robert Crais, Lee Child (right. Mike?), James Lee Burke(thanks, Kevin!), Nelson DeMille, James Patterson, Karin Slaughter, Joseph Wambaugh, Carl Hiassen, the Vince Flynn series (Vince Flynn and after his death, Kyle Mills), Stieg Larsson (Dragon Tatoo series- and after his death, David Lagercrantz), the KIlling series by Bill O'Reilly + Martin Dugard, Dan Brown, David Baldacci, Steven King,   and for those fans of historical fiction books with about 1000 pages and small print - James Michener.  That should keep everyone busy well through the pandemic!!  Enjoy everyone's take on current affairs from the Mikes to Dr. Jim.  Suspect right perspective somewhere in between. 


04/23/20 03:32 PM #7233    

Timothy Lavelle

Al, Great list. Thanks. James Lee Burke can't be beat. Can I add a couple ala James Lee? Dennis LeHane and of course Elmore Leonard.

And, a story. My oldest bro's first wife passed away many years ago. My sister decided she had "just the right girl" for her widower brother. Mary Connelly, (a gorgeous and wonderful woman and Michael's mother) lived out the rest of her life married to my hero, Jack LaVelle. I think it was ""Blood Work"  that has a dedication to Jack n Mary. Michael takes no plot advice from me or he would be a bestseller by now! 


04/23/20 07:28 PM #7234    

 

David Mitchell

Dare I throw in Pat Conroy - who's book "Prince of Tides" was writtien with my Bluffton as it's (unnamed) setting (while he lived here). 

And who would be so silly as to think a story about a University of Washington rowing team in the 1930's could possibley be interesting? "The Boys in the Boat"  by Daniel James Brown is wonderful - much deeper than a bunch of college guys rowing! 

Anybody like Jon Krakauer? I read "Into Thin Air" and loved it. His "Into The Wild" was a great read too, but rather depressing.  And Still hoping to read his expose of fundamental Mormonism, "Under the Banner Of Heaven". My son doesn't read much but he said he couldn't put this one down.

Krakauer is just plain interesting. He has seveal other books, and came under attack (at first) for exposing the financial fraud of the author of "Three Cups of Tea" in his own book "Three Cups of Deceipt". 

My (now published author) oldest daughter (who I believe eats books for lunch), gave me a book years ago that I thought was too long for me. It was David James Duncan's "The Brothers K". A disfunctional family in Washington State with a pair of parents not coping well, and four very different sons. Wow, was I wrong to think it would be too long for me.  Wonderful read once you get into it! 

If you have the stomach for a deep dive into one of the 20th Century's greatest inhumanities (and best kept secrets), try "The Rape of Nanking" by the late Iris Chang. She is (was) a Chinese American scholar who gives an in-depth account of the Japanese occupation and systematic slaughter of 300,000 to 400,000 Chinese citizens in the City of Nanking around 1937. It will shock you to the core. My dad had a similar book and shared a bit of this story with me as a boy. The Japanese refer to it as the "Nanking Incident" and have done everything they can over the last 70+ years to keep the facts out of public scrutiny.

The current day Japanese press harrased this American author so harshy that she fell into a depression and commited suicide.

The story has three shocking elements; First, that the mass killings actually happened, Second, that a small "International" safe section was left for the American, British, Australian, and German, residents to live in safely, and Third, that those same international citizens were given no credibilty whatsoever by the Western Press when the war was over and they tried to tell their story to the world.

I can only imagine Mark could have a field day with his historic research on this one.    

 


04/23/20 07:41 PM #7235    

 

Alan Standish

Tim- It wasn't "Blood Work", but "A Darkness More Than Light", released in 2001(his 10th book) that he dedicated "this is for Mary and Jack Lavelle who proved there are second acts".  He must have overcome any advice you gave him, because he went on to write 34 books and create and executive produce the Amazon TV series "Bosch", based on his character Hieronymous (Harry) Bosch-now in it's 6th season!  I'm duly impressed!!


04/23/20 07:43 PM #7236    

 

David Mitchell

And Al,

Love that you threw in Michener. I started reading books again in Vietnam with the advice of a buddy. I had literally taken a book out of the trash can down on the fligh tline one day. It was Taylor Caldwell's "Grandmother And the Priests". I only grabbed it because I recognized it from my mother's bedside night stand at home. I loved it, but then I was hungry for something more to read.

Same buddy gave me "The Fires of Spring" by Michener. It is not considered that great of a book, but it holds a place of special reverence on my book shelf. 

 

But now I feel I am at a disadvantage. Every time I try to read anything of any length at all, my eyelids suddently become like lead weights. I confess in recnet years, most of my serious reading has been while I am driving and listening to DVDs.  

Is this considiered cheating?

 

 


04/23/20 09:04 PM #7237    

 

Mary Ann Nolan (Thomas)

Actually Dave Pat Conroy was from Beaufort, graduated from Beaufort High. He then taught on Daufuskee Island.Then went to the Citadel.He actually became a good friend of ours here in Beaufort. We had book signings at our Inn here in Beaufort and had his 70th birthday celebration at our place. He is now bured on St. Helena . The Pat Conroy literature  center is in downtown Beaufort.


04/24/20 09:06 AM #7238    

 

Alan Standish

Dave, I (vaguely) remember enjoying "The Fires of Spring" sometime in my teens.  Just finished "The Source"- kinda tough to get through, but very interesting!  Best thing about Michener is that you always learn something (whether you want to or not!)  I remember seeing the movie "The Prince of Tides" sometime in the early 90s and then reading the book later.  Enjoyed the book more than the movie!


04/24/20 11:10 AM #7239    

 

Deborah Alexander (Rogers)

I am a huge Pat Conroy fan too!  I've read every one of his books, and loved every one.  His Catholic upbringing is an important part of his stories which makes the books very relatable.  If you want to read great family sagas, read Pat Conroy!  Mary Ann, how lucky for you that you got to meet him and have him as a friend.  I loved reading his books when down in the Low Country each summer, and I so wish there were more.  


04/24/20 11:46 AM #7240    

 

Michael McLeod

https://twitter.com/sarahcpr/status/1253474772702429189?s=20&fbclid=IwAR1EtKT_csBbc5MaGaiZ_FRAfCMZUk7l1a52xMLd2uNDmmZCfmbC58s8zj0


04/24/20 11:52 AM #7241    

 

David Mitchell

Mary Ann,

 

You are corrrect.

I should have added all that. But he did live in Bluffton for a short period while he was writing "Prince of Tides". My best friend (cobra pilot, house & boat builder) also knew him while he lived here. There is a property near us where he lived in an old double-wide, owned by one of his father's old Marine buddies. 

And yes, hIs life did revolve mostly around Beaufort and Charleston, but I think he moved away to Rome (Italy) for many years before his short period back in his favorite Beaufort - just before he died. We probably both will remember how much the local press made out of his death. You'd have thought it was the end of the world in Beaufort.

(I have bragged - jokingly -  to my kids that I have something in common with Pat Conroy. That he and I both were the featured article on the Sunday front page of the Beaufort Gazette (and Hilton Head "Island Packet"), and both with articles written by David Lauderdale - a favorite local reporter). But Pat conroy was featured two weeks in a row. I only made it once - LOL.  

 

Correct me if I am wrong here:

He angered so many people with his outspoken critical manner (though well desrved when he spoke out about local racism in the school system) that he was shunned by many and even banned from events at his alma mater, The Citadell ("Lords of Discipline") for years. But times changed. When he was burried frrom St. Peter's Catholic Church in Beaufort a few years ago, the Citidel sent a large contingent of cadets, who I was told, lined the entire walkway from the parking lot to the church door as an honor guard. 

It is said that he had been widely disliked for his abrasive manners (due to his manic depression), but seemd to come back to his beloved Beaufort in those last few years a changed man - staying on his meds, and with a third wife who helped him take the "edge" off his temper. Before returning full-time, he had been comming back to Hilton Head every year to give a keynote speech for local mental health charities.  

You should share a bit more about some of your guests at your Inn, such as Blythe Danner, who was the wife in "The Great Santini", with Robert Duval (another good Conroy book and movie). And you might eplain a bit more about all the films shot in and around Beaufort. 

A friend here is Bluffton is a semi-retired graphic artist, with a connection to the semi-retired movie producer in Beaufort. Every time Hollywood comes to shoot in the Beaufort area, she has done virtually every highway sign, bus decal, restaurant sign and menu, logo, old business sign, etc.  for "The Great Santini", "Prince of Tides", "The Big Chill", "Taladega Nights", "The Note Book", and others for many years. She did not do Forrest Gump, but her husand's family farm land was used for the construction of the boyhood home - an empty shell that was then torn down after the filming. 

----------------

Al,

Yes, the book is almost always better than the movie. And they left out a major plot line in the "Prince" - his brother's post Vietnam PTSD issues and the Savannah river nuclear plant.

Interestingly, another really good locally written book/movie, "The Secret Life of Bees" (Gina Prince Bagwood) stayed quie faithfull to the book. Four black ladies and a little runaway white girl in South Carolina in the 50's. 

 


04/24/20 12:03 PM #7242    

 

David Mitchell

Mike,

Do you suppose it would work if I swallow a tiny flashligh?

But I already have enough acid in my stomach that I probably don't need to swallow any batteries. 


04/24/20 03:35 PM #7243    

 

David Mitchell

Have you seen this? I'd say that's one mighty savvy asteroid!

(appears to be wearing a mask) 

 


04/24/20 04:03 PM #7244    

 

John Jackson


04/24/20 05:49 PM #7245    

Mary Clare Hummer (Bauer)

Mike, I was thinking about posting the link you gave us but you beat me to it. It is so funny.  Yet also disturbing that the head of the executive branch of the government of the United States actually voiced these preposterous ideas. Today, of course, he says he was being sarcastic. Guess he doesn't understand the nuances of language any more than the tenets of medicine. 
Wash your hands, everybody. ❤️
Clare

 


04/24/20 07:37 PM #7246    

 

James Hamilton, M. D.

Mike's video post and John's Clorox picture were, indeed, funny and sarcastic in their own right. And I am sure that we are all smart enough to recognize sarcasm and the way President Trump likes to spar with the press.

Mike, I was wondering if Sarah Cooper has made any funny videos of the likely Democratic nominee's speaking problems. That would probably be mean as I do not think Joe Biden's miscues are intentional or meant to be sarcastic. 

To get purely medical for a moment, injecting or ingesting household chemical poisons is NOT a good form of treatment and it is often posted boldly on the containers. That being said, many poisonous substances are used therapeutically to treat certain diseases both today and in the past (think chemotherapy).

Fever therapy was common in the 1930's but is rarely used today. You would be surprised to find out how the true fevers - not just hyperthermia - were induced! I shall let you all do your homework on that one 🤔. 

We are all aware of both the dangers of radiation and the benefits of radiation therapy.

Light therapy from lasers to UV treatment is beneficial in many disorders. Some of these are actually used internally.

Will the future bring to use things we consider unconscionable today? I would not bet against it. Just my thoughts... 

Jim 

 

 


04/24/20 07:56 PM #7247    

 

John Jackson

Jim,  I guess I'm not smart enough because I didn't  detect a trace of sarcasm in Trump's coronavirus briefing last night where he suggested Clorox, Lysol, etc might do the trick - it seemed dead serious to me. Did you actually see what he said? 


04/24/20 08:06 PM #7248    

 

James Hamilton, M. D.

John,  

Yes, I did. I heard it and I read it later, twice.

Jim  

ADDENDUM :  

John,  It is probably all in the way we view President Trump.

 


04/24/20 11:03 PM #7249    

 

Mary Margaret Clark (Schultheis)

Disclaimer..... I did not vote for Donald Trump.

Regarding the comments made by the President in Thursday's press briefing (which I watched) during which he pondered aloud (but did not suggest or recommend) whether or not heat and UV light or disinfectant that have proved effective at killing COVID-19 on surfaces could somehow be administered inside the body to treat patients suffering from the disease.  An AP press release on April 20th provides the context of Trump's comments. The news report announced a novel treatment developed by scientists at Cedars-Sinai that administers UV light inside the bodies of patients inflicted with respiratory infections. They are currently working with the FDA to explore an expedited regulatory process to use the treatment as a possible medical intervention for those suffering from the coronavirus   

(Via AP)

[Aytu BioScience, Inc. (the “Company”)], a specialty pharmaceutical company focused on commercializing novel products that address significant patient needs announced today that it has signed an exclusive worldwide license from Cedars-Sinai to develop and commercialize the Healight Platform Technology (“Healight”). This medical device technology platform, discovered and developed by scientists at Cedars-Sinai, is being studied as a potential first-in-class treatment for coronavirus and other respiratory infections.

The Healight technology employs proprietary methods of administering intermittent ultraviolet (UV) A light via a novel endotracheal medical device. Pre-clinical findings indicate the technology’s significant impact on eradicating a wide range of viruses and bacteria, inclusive of coronavirus.

“Our team has shown that administering a specific spectrum of UV-A light can eradicate viruses in infected human cells (including coronavirus) and bacteria in the area while preserving healthy cells,” stated Dr. Pimentel of Cedars-Sinai. Ali Rezaie, MD, one of the inventors of this technology states, “Our lab at Cedars-Sinai has extensively studied the effects of this unique technology on bacteria and viruses. Based on our findings we believe this therapeutic approach has the potential to significantly impact the high morbidity and of coronavirus-infected patients and patients infected with other respiratory pathogens.

Addendum:

While doing some further reading I came across this interesting info on how Chris Cuomo and his wife were dealing with their COVID-19 illness.  This is excerpted from Cristina's blog:

At the direction of my doctor, Dr. Linda Lancaster, who reminded me that this is an oxygen-depleting virus, she suggested I take a bath and add a tiny amount of sodium hypochlorite in the form of Clorox, as a type of homeopathic bath, and I mean a 1/4 cup of bleach which in an 80 gallon water tub is a ratio of 1:5000. Why? To combat the radiation and metals in my system and oxygenate it. “We want to neutralize heavy metals because they slow up the electromagnetic frequency of our cells, which is our energy field, and we need a good flow of energy. Clorox is sodium chloride—which is technically salt. Clorox is made by introducing an electric current to water and sodium chloride (saline) creating sodium hypochlorite. There is no danger in doing this. It is a simple naturopathic treatment that has been used for over 75 years to oxygenate the cells,” says Dr. Lancaster. “Household bleach is not chlorine.” I found information on this and read it first–in Dr. Lancaster’s Harmonic Healing book and the chapter on heavy metals, as well as in some articles... showing that it used in the medical world and the alternative medicine world.........OK, so feeling a little less apprehensive about this detox that isn’t FDA approved after reading these articles, and since I had no sense of smell and no open wounds that it might sting, I opted to try it once. I added a small amount—1/4 to ½ cup ONLY—of Clorox to a full bath of warm water (80 gallons). “We are all exposed to radiation (phone/Wi-Fi) and that agitates our cells,” says Lancaster, who also recommended a sea salt (1 pound) and baking soda (1 full box) bath to help with this too. “We have never recommended the baths as any type of cure. We utilize this bath to aid the body in the detox process of chemicals and environmental pollutants,” says Lancaster.


04/25/20 12:02 PM #7250    

Timothy Lavelle

The scene: Gone With the Wind (currently renamed "Trump Re-election, 2020").

A group is standing in front of Tara as the mansion burns. A union soldier turns to the mistress of the estate and says, "I want you to know I didn't vote for Lincoln".

A leader is supposed to have the ability to lead. Sort of a prime requisite. That means he/she has to have the ability to instill in strangers the confidence in his/her goals and plans. Often times, it helps to be rational. Actions like overuse of meaningless conversation or lying to the public and press could be seen as counter to instilling confidence.

I like the UK and (I think) Australia's procedure for voting "no confidence" as a way of getting rid of ineffective leaders. Certainly a singular lack of confidence by large numbers of voters is a hallmark of the current administration. 


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