James Hamilton, M. D.
Sorry I could not respond earlier today; it has been a busy one.
Frank,
Good stuff, thanks for bringing it up! The Castor Oil Plant is known for castor oil (Duh!!!) which many of our mothers probably gave us when we got constipated as kids. Yuck!! Today it is more famous for a substance found in it's seeds known as ricin, a highly neurotoxic poison which can be used in terrorist and other nefarious attacks.
Jimson Weed is full of anticholanergic substances which have many bona fide medical applications but, when taken in excess, can cause those sxs I discussed above in Post #6314. In the plant the seeds and leaves contain the highest concentration of these chemicals.
Foxglove is the source of digitalis, also a poison, that has been used for various cardiac conditions for a couple of centuries, but has mostly been replaced by more modern therapies.
There are hunrdeds if not thousands of plants in the world that contain chemicals that have, and potentially have, medical applications, many as yet undiscovered.
Mike,
The death of George Washington has been debated in medical circles for years. I doubt that it will ever be completely solved as it was somehow related to soft tissue infection so, even if his body could be exhumed, a definitive diagnosis would be unlikely with present technology. We know that it was some kind of upper respiratory infecion, probably bacterial in etiology, and most belive a Streptococcus infection. I think Haemophilus also could have been the pathogen. Many things including pharyngitis, peri-tonsillar abcess ("quinsy"), tracheitis and epiglotitis have been considered. Also, as I discussed a little bit in Post #6318, the treatment has been blamed for his death: blood letting. Blood letting by incision, leeches, etc. was State of the Art back then to "release bad humours" from the body. Today it is still in use in some primitive cultures but also occasionally for some diseases like hemochromatosis (iron overload) and polycythemia (too many red blood cells).
Some believe Washington could have been saved by a tracheotomy which was just coming into practice. However, the technique was not refined at that time and, in itself, could have been fatal.
The most likely conclusion was death due to suffocation from epiglotitis.
Alexander Hamilton's death was due to a gunshot wound. I guess he was "gut shot". In the Old West being gut shot was a bad way to go: painful and often not immediate. Since Hamilton died the next day, the projectile probably missed major vessels like the aorta and inferior vena cava. There are so many organs in the abdominal cavity that blood loss from them could have been the cause. I would doubt that a fatal infection could have ocurred that quickly.
Stay tuned for the next historical medical quiz,
Jim
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